The evidence could shed light on further clinical studies to improve osteogenesis in bone graft surgeries.īone is a metabolically active tissue that undergoes constant remodeling throughout one's life. The main objective of the present paper is to comprehensively outline the preclinical studies on the properties of vitamin K and its effects on the bone metabolism. There is also credible evidence to support the effects of vitamin k2 on differentiation of other mesenchymal stem cells into osteoblast. Vitamin K exerts its anabolic effect on the bone turnover in different ways such as promoting osteoblast differentiation, upregulating transcription of specific genes in osteoblasts, and activating the bone-associated vitamin k dependent proteins which play critical roles in extracellular bone matrix mineralization. Accordingly, vitamin K as a multifunctional vitamin has been recently deemed appreciable as a topic of research as it plays a pivotal role in maintenance of the bone strength, and it has been proved to have a positive impact on the bone metabolism. Cytokines along with several hormonal, nutritional, and growth factors are involved in tightly regulated bone remodeling. Bone is a metabolically active tissue that renews itself throughout one's life.
0 kommentar(er)
